Nolpase: instructions for use, analogues, for what purpose

The occurrence of heartburn is associated with an increase in the acidity of the digestive juice in the stomach. Popular antacids bring only temporary relief, relieving the symptoms of an unpleasant phenomenon. An effective modern remedy for eliminating the causes of heartburn is Nolpaza, the instructions for use of which are described in detail below.

Composition, release form and packaging

The active component of Nolpase is pantoprazole, which is contained in it in an amount of 20 or 40 mg.

In addition to the active substance, the agent contains substances necessary for the correction of the structure and color of the tablets, the formation of a special shell:

• mannitol;
• crospovidone;
• soda ash;
• emulsifiers;
• sweeteners;
• dyes and pigments;
• talc;
• hypromellose;
• povidone and others.

The drug is available in oblong tablets, yellowish light brown in color. The tablets have a special enteric coating. A brownish-white solid mass will be visible at the fault location.

Nolpaza tablets are placed in silver opaque blisters and packed in a cardboard box with a label containing information on the composition, quantitative content of the active substance, shelf life. The package can be 14 or 28 tablets.

Also, Nolpaza is produced in the form of a lyophilisate (a kind of powder) to obtain a solution that is administered intravenously. The powder is packaged in mini glass bottles placed in a cardboard box of 10 or 20 doses.One container contains 40 mg of pantoprazole. In addition to it, mannitol, sodium citrate dihydrate, and caustic soda are present in the lyophilisate.

Pharmacological action, pharmacodynamics and pharmacokinetics

Nolpaza is a medicine that reduces the production of digestive juice in the stomach. The mechanism of action of the drug is based on the neutralization of the so-called proton pump.

As you know, the composition of the gastric juice includes hydrochloric acid, which is formed in the cells of the stomach from chlorine and hydrogen protons. The enzyme H + -K + -ATPase, which is also called a proton pump (pump), transfers a hydrogen proton through the cell membrane, completing the process of producing hydrochloric acid. Pantoprazole (the active component of the drug) neutralizes the enzyme, disrupting the final stage of acid production, which reduces acidity in the stomach.

Pantoprazole is absorbed in the intestine in a short time, its maximum content in the blood plasma is reached 2.5 hours after administration and is maintained throughout the duration of therapy. The relationship of the drug with blood proteins is 98%. Pantoprazole is biotransformed by the liver, most of its metabolic products come out in the urine.

What is Nolpaza prescribed for?

Before taking Nolpazy, you should find out why this medicine is prescribed. According to instructions, the drug is used in the pathology of the digestive system, for the treatment of which it is necessary to reduce the formation of hydrochloric acid by the cells of the stomach.

These include:

• stomach ulcer and duodenal ulcer;
• gastroesophagic reflux disease - inflammation of the walls of the esophagus caused by the constant ingestion of the contents of the stomach;
• Zollinger-Ellison syndrome - a set of symptoms that develop against the background of a neoplasm in the pancreas or duodenum, due to which the secretion of acid from the digestive juice increases, which has a destructive effect on the mucosa;
• diseases caused by microorganisms Helicobacter pylori (in combination with antibiotics).

Nolpaza is also suitable for preventing ulceration of the gastrointestinal mucosa during long-term treatment with non-steroidal anti-inflammatory drugs (Diclofenac, Ketoprofen, etc.), treatment of gastritis with high acidity, pancreatitis (to relieve inflammation), dyspeptic disorders caused by hypersecretion of hydrochloric acid (heartburn, heartburn, sour taste, etc.)

Instructions for use and dosage

Nolpaza tablets are drunk before meals, before breakfast, or before breakfast and dinner.

The dosage regimen depends on the type and degree of pathology:

1. With gastroesophagic reflux, heartburn, belching: from 20 to 80 mg per day for up to two months. It is allowed to use "Nolpaza" if necessary, if there are signs of dyspepsia.
2. Peptic ulcer of the stomach and duodenum, gastritis: 40-80 mg per day from 2 weeks to 2 months.
3. Treatment of diseases caused by Helicobacter pylori: 40 mg twice daily for up to 2 weeks.
4. Other conditions characterized by increased production of hydrochloric acid: initial dose - 80 mg per day. Further, it is allowed to change depending on the condition of the patient.

Lyophilisate for solution preparation is administered intravenously exclusively by medical personnel.

During pregnancy and lactation

During pregnancy and natural feeding, Nolpazu is taken exclusively as prescribed by the doctor if the expected beneficial effect for the woman is higher than the probable risk to the fetus and child. There is no evidence of pantoprazole in breast milk.

Nolpase Compatibility with Alcohol

According to the instructions, significant interactions of ethanol and pantoprazole were not detected. Despite this, experts strongly recommend that you refrain from drinking alcohol during treatment, since both of these substances, like all Nolpaza analogues, are metabolized by the liver.

Alcohol consumption together with the drug significantly increase the burden on the body, which can provoke a disruption in its work. In addition, in diseases of the gastrointestinal tract, which are treated with the help of "Nolpaza", drinking alcohol is extremely undesirable or completely contraindicated.

Drug interaction

The following interactions with other groups of drugs are characteristic of Nolpaza:

• "Nolpase" can reduce the absorption of drugs whose bioavailability is affected by the pH of the digestive juice - these include some drugs to eliminate the fungus (ketoconazole, itraconazole, etc.), drugs for the treatment of HIV infection;
• with the combined use of pantoprazole and anticoagulants, blood coagulation indicators rarely change;
• with the combined use of pantoprazole and methotrexate in some patients, an increase in the concentration of the latter is observed.

Contraindications, side effects and overdose

Nolpazu is not used in the following cases:

• intolerance to pantoprazole and other components of the drug;
• fructose intolerance;
• dyspeptic failures on the background of neurotic disorders;
• age up to 18 years (due to lack of information).

With caution, Nolpase is prescribed for pregnant, lactating, persons with liver dysfunction and a high risk of a deficiency of cyanocobalamin (vitamin B12).

According to clinical trials, 95% of the subjects tolerated Nolpaza therapy well. Very rarely, patients may experience side effects related to certain systems of the body.

Adverse events are indicated in the table:

Body system	Side effects
Digestive	•abdominal pain; • stool disorders; • increased gas formation.
Musculoskeletal	•arthralgia; • myalgia.
The immune system	anaphylactic reactions.
Nervous	•headache; • dizziness; • visual impairment.
Hematopoietic organs	• leukopenia; • thrombocytopenia.

Allergic manifestations, weakness, tenderness of the mammary glands are not excluded. In the event of serious adverse reactions, it is necessary to stop taking the drug and consult a specialist.

Analogues of the drug

In addition to Nolpaza, pantoprazole as an active ingredient is contained in the following tablet formulations:

• Zipantola (Croatia);
• "Controlok" (Germany);
• “Krosatsid”, “Pantaz”, “Panum” (India);
• Peptazole (Argentina);
• "Pizhenum - Sanovel", "Puloref" (Turkey);
• Ultera (USA)

In addition to pantoprazole, proton pump inhibitors also include omeprazole, lansoprazole, rabeprozole, and esomeprazole. The most famous of them is omeprazole (Omez), which is widely used by gastroenterologists. Specialists have different answers to the question, which is better: “Omez” or “Nolpaza”. On the one hand, Omez is an old proven drug, on the other, Nolpaza is a newer and more effective means of European quality. Recently, modern specialists are increasingly appointing Nolpazu patients.

Which is better, Control or Nolpaza

“Kontrolok” is perhaps the most famous full analogue of “Nolpaza”. Since the active substance of both drugs is pantoprazole, a reasonable question arises, which is better: "Control" or "Nolpaza". "Control" is an original medication, i.e. the first drug in which pantoprozole substance was used, which has undergone extensive clinical trials. Nolpaza is a generic drug, a less expensive drug that begins to be produced a little later and is not subjected to numerous studies. Generic manufacturers are based on test data from the original drug.

Many experts recommend taking only original drugs, referring to their undeniable quality. But in the case of Nolpaza, things are somewhat different. Nolpaza is a very high-quality generic, the effectiveness of which will be confirmed by many practicing gastroenterologists.Therefore, if finances do not allow you to purchase Controlok, it is quite possible to replace it with Nolpaza.